Thesis
Mechanisms underlying the endogenous neuroprotection of hamartin in ischaemic stroke
- Abstract:
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Introduction: Hamartin has been shown to mediate the endogenous resistance of Cornu Ammonis 3 (CA3) neurons to ischaemia. Proposed mechanisms concern the inhibition of mammalian target of rapamycin (mTOR) which could promote productive autophagy and prevent endoplasmic reticulum (ER) stress. A small molecule targeted at these pathways could protect neurons and buy valuable time for recanalization therapy for stroke.
Methods: In vivo, the modified four vessel occlusion model of glob...
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Funding
Oxford University Clinical Academic Graduate School
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:1560ec7f-15cb-4c2d-b55d-2ac2bc653dfd
- Deposit date:
- 2016-04-25
Terms of use
- Copyright holder:
- Hadley, G
- Copyright date:
- 2016
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