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Mechanisms underlying the endogenous neuroprotection of hamartin in ischaemic stroke

Abstract:

Introduction: Hamartin has been shown to mediate the endogenous resistance of Cornu Ammonis 3 (CA3) neurons to ischaemia. Proposed mechanisms concern the inhibition of mammalian target of rapamycin (mTOR) which could promote productive autophagy and prevent endoplasmic reticulum (ER) stress. A small molecule targeted at these pathways could protect neurons and buy valuable time for recanalization therapy for stroke.

Methods: In vivo, the modified four vessel occlusion model of glob...

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Institution:
University of Oxford
Oxford college:
Harris Manchester College
Role:
Author

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Role:
Supervisor
Oxford University Clinical Academic Graduate School More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1560ec7f-15cb-4c2d-b55d-2ac2bc653dfd
Deposit date:
2016-04-25

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