Thesis
The development and application of new hyperpolarized magnetic resonance spectroscopy techniques for the non-invasive assessment of metabolism in the rodent heart
- Abstract:
-
The aim of this thesis was to develop and apply new hyperpolarized magnetic resonance spectroscopy techniques, to assess in vivo metabolism in the rodent heart. Initial work using rat models of heart disease has provided key findings, such as significant increases in pyruvate dehydrogenase flux in the hypertensive rat heart and metabolic alterations in the TCA cycle during the progression into heart failure. Both could provide future non-invasive markers for the metabolic alterations...
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Authors
Contributors
+ Tyler, D
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
+ Ashrafian, H
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
+ Watkins, H
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
+ Casadei, B
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:153b884e-b6dc-482e-bc48-7e6b9a457bbd
- Local pid:
- ora:8503
- Deposit date:
- 2014-06-03
Terms of use
- Copyright holder:
- Michael Dodd
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
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