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Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization

Abstract:

Vaccines have revolutionized public health, preventing millions of deaths each year, particularly in childhood. Yet, there is considerable variability in the magnitude and persistence of vaccine-induced immunity. Maintenance of specific antibody is essential for continuity of vaccine-induced serological protection. We conducted a genome-wide association study into the persistence of immunity to three childhood vaccines: capsular group C meningococcal (MenC), Haemophilus influenzae type b, and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2019.05.053

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Strategic
Oxford college:
Magdalen College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
27
Issue:
11
Pages:
3241-3253
Publication date:
2019-06-11
Acceptance date:
2019-05-15
DOI:
EISSN:
2211-1247
Source identifiers:
1010675
Keywords:
Pubs id:
pubs:1010675
UUID:
uuid:14c3b915-281a-44fd-8199-5ad2887f0be4
Local pid:
pubs:1010675
Deposit date:
2019-06-11

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