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Opioid antagonists and the A118G polymorphism in the μ-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype

Abstract:

The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on alcohol-related behaviors, and on opioid receptor antagonist treatments, have been inconsistent. We investigated the pharmacogenetic interaction between A118G variation and the effects of two μ-opioid receptor antagonists in a clinical lab setting. Fifty-six overweight and moderate–he...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/npp.2016.60

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Role:
Author
ORCID:
0000-0003-4044-1719
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GlaxoSmithKline (GSK) More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Neuropsychopharmacology Journal website
Volume:
41
Issue:
11
Pages:
2647-2657
Publication date:
2016-04-25
Acceptance date:
2016-04-06
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Pmid:
27109624
Source identifiers:
1033405
Language:
English
Subjects:
Pubs id:
pubs:1033405
UUID:
uuid:125de12b-169a-4fc5-be91-a19e2984a353
Local pid:
pubs:1033405
Deposit date:
2019-07-18

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