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AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system

Abstract:

Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and co-factors essential to protein stability, reactivity, or enzyme-substrate complex formation. The regulation of potassium ion movement in bacteria is predominantly under the control of regulatory ligands that gate the relevant channels and transporters, which possess subunits or domains that contain Rossmann folds (RFs). Here we demonstrate ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.biochem.7b00300

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Funding agency for:
Chan, A
Grant:
Marie Curie Fellowship 660156, FLUOROKEF
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Funding agency for:
Cortopassi, W
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Grant:
WT092552MA, WT100209MA to IRB, JHN, SM, and SJC
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Grant:
Marie Curie ITN Award (NICHE; 289384) that supported SE
Publisher:
American Chemical Society Publisher's website
Journal:
Biochemistry Journal website
Volume:
56
Issue:
32
Pages:
4219–4234
Publication date:
2017-06-28
Acceptance date:
2017-06-28
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
702420
Language:
English
Keywords:
Pubs id:
pubs:702420
UUID:
uuid:11ee88d0-6699-4a63-9418-89f9ac7057c3
Local pid:
pubs:702420
Deposit date:
2017-07-02

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