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AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system

Abstract:

Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and co-factors essential to protein stability, reactivity, or enzyme-substrate complex formation. The regulation of potassium ion movement in bacteria is predominantly under the control of regulatory ligands that gate the relevant channels and transporters, which possess subunits or domains that contain Rossmann folds (RFs). Here we demonstrate ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/acs.biochem.7b00300

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Funding agency for:
Chan, AKN
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Funding agency for:
Cortopassi, WA
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Grant:
WT092552MA, WT100209MA to IRB, JHN, SM, and SJC
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Grant:
Marie Curie ITN Award (NICHE; 289384) that supported SE
Publisher:
American Chemical Society Publisher's website
Journal:
Biochemistry Journal website
Volume:
56
Issue:
32
Pages:
4219–4234
Publication date:
2017-06-28
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Pubs id:
pubs:702420
URN:
uri:11ee88d0-6699-4a63-9418-89f9ac7057c3
UUID:
uuid:11ee88d0-6699-4a63-9418-89f9ac7057c3
Local pid:
pubs:702420

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