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The potential of fosfomycin for multi-drug resistant sepsis: an analysis of in vitro activity against invasive paediatric Gram-negative bacteria

Abstract:

Purpose: Antimicrobial resistance (AMR) is of increasing global concern, threatening to undermine recent progress in reducing child and neonatal mortality. Repurposing older antimicrobials is a prominent strategy to combat multidrug-resistant sepsis. A potential agent is fosfomycin, however, there is scarce data regarding its in vitro activity and pharmacokinetics in the paediatric population.

Methodology: We analysed a contemporary, systematically collected archive of community-acq...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/jmm.0.000973

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
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Publisher:
Microbiology Society Publisher's website
Journal:
Journal of Medical Microbiology Journal website
Volume:
68
Issue:
5
Pages:
711-719
Publication date:
2019-04-17
Acceptance date:
2019-03-16
DOI:
EISSN:
1473-5644
ISSN:
0022-2615
Source identifiers:
987626
Keywords:
Pubs id:
pubs:987626
UUID:
uuid:11c26afe-bb1a-462e-be77-aad1c11132dc
Local pid:
pubs:987626
Deposit date:
2019-04-12

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