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High precision Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing

Abstract:

The rise of antimicrobial-resistant Neisseria gonorrhoeae is a significant public health concern. Against this background, rapid culture-independent diagnostics may allow targeted treatment and prevent onward transmission. We have previously shown metagenomic sequencing of urine samples from men with urethral gonorrhea can recover near-complete N. gonorrhoeae genomes. However, disentangling the N. gonorrhoeae genome from metagenomic samples and robustly identifying antimicrobial resistance de...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gr.262865.120

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Pembroke College
Role:
Author
ORCID:
0000-0001-6370-1961
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-1475-8248
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genome Research Journal website
Volume:
30
Issue:
9
Pages:
1354-1363
Place of publication:
United States
Publication date:
2020-09-01
Acceptance date:
2020-07-27
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Pmid:
32873606
Language:
English
Keywords:
Pubs id:
1130183
Local pid:
pubs:1130183
Deposit date:
2020-10-20

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