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A diurnal rhythm in brown adipose tissue causes rapid clearance and combustion of plasma lipids at wakening

Abstract:

Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.03.004

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-0014-5571
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
22
Issue:
13
Pages:
3521-3533
Publication date:
2018-03-27
Acceptance date:
2018-02-28
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
29590620
Source identifiers:
833884
Language:
English
Keywords:
Pubs id:
pubs:833884
UUID:
uuid:10e51b09-0618-4b0c-a102-c192e8ccd31d
Local pid:
pubs:833884
Deposit date:
2019-02-13

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