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Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates.

Abstract:

BACKGROUND: Var genes encode a family of virulence factors known as PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and cytoadherence of infected erythrocytes. Although these molecules play a central role in malaria pathogenesis, the mechanisms generating variant antigen diversification are poorly understood. To investigate var gene evolution, we compared the variant antigen repertoires from three geographically diverse parasit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2164-8-45

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Contributors

MJ Murdock Charitable Trust More from this funder
National Institute of Allergy and Infectious Diseases More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC genomics Journal website
Volume:
8
Pages:
Article no. 45
Publication date:
2007-01-01
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Source identifiers:
12013
Language:
English
Keywords:
Pubs id:
pubs:12013
UUID:
uuid:0f42a30e-0745-4ae5-8886-c4b3b8ef6c59
Local pid:
pubs:12013
Deposit date:
2012-12-19

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