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Journal article

Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics

Abstract:

Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune responses, co-infection, viral genetics, and adaptation. Here, we develop a new ‘‘relaxed-clock’’ phylogenetic method to estimate absolute rates of synonymous and nonsynonymous substitution through time. We identify an unexpected association bet...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
doi:10.1371/journal.pcbi.0030029

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Research group:
Evolutionary Biology
Role:
Author
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Institution:
University of California San Diego
Department:
Department of Pathology
Role:
Author
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Institution:
University of Auckland
Department:
Department of Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Research group:
Evolutionary Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Research group:
Evolutionary Biology
Role:
Author
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Contributors

Institution:
University of Auckland
Role:
Editor
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Funding agency for:
Lemey, P
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Funding agency for:
Pybus, O
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Funding agency for:
Barroso, H
Grant:
POCTI/ESP/48045/2002
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Funding agency for:
Shapiro, B
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Publisher:
Public Library of Science
Journal:
PLoS Computational Biology Journal website
Volume:
3
Issue:
2
Pages:
e29
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
Subjects:
UUID:
uuid:0f04da8a-34e9-4404-9084-5b1aa9d79eed
Local pid:
ora:965
Deposit date:
2008-03-14

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