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Journal article

CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner

Abstract:

Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has been proposed as a tumor specific anti-cancer target. Here we show that the effects of CDK1 inhibition are not restricted to tumor cells but can also reduce viability in non-cancer cells and sensitize them to radiation in a cell cycle dependent manner. Radiosensitization by the specific CDK1 inhibitor, RO-3306, was determined by colony fo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/15384101.2018.1491236

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0001-5196-0552
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
ORCID:
0000-0001-8862-3613
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-9437-0253
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Medical Research Council More from this funder
More from this funder
Funding agency for:
Higgins, G
Grant:
C34326/A19590
Cancer Research More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Cell Cycle Journal website
Volume:
17
Issue:
12
Pages:
1513-1523
Publication date:
2018-07-25
Acceptance date:
2018-06-13
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Pmid:
30045664
Source identifiers:
891320
Language:
English
Keywords:
Pubs id:
pubs:891320
UUID:
uuid:0eb53f04-e817-4282-a3b8-e39fb5052236
Local pid:
pubs:891320
Deposit date:
2018-11-16

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