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 Amplicon-based detection and sequencing of SARS-CoV-2 in nasopharyngeal swabs from patients with covid-19 and identification of deletions in the viral genome that encode proteins involved in interferon antagonism

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Sequencing the viral genome as the outbreak progresses is important, particularly in the identification of emerging isolates with different pathogenic potential and to identify whether nucleotide changes in the genome will impair clinical diagnostic tools such as real-time PCR assays. Although single nucleotide polymorphisms and point mutations occur during the replicati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/v12101164

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Role:
Author
ORCID:
0000-0002-0653-2097
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Role:
Author
ORCID:
0000-0002-7642-4534
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Role:
Author
ORCID:
0000-0002-3775-9585
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Publisher:
MDPI Publisher's website
Journal:
Viruses Journal website
Volume:
12
Issue:
10
Article number:
1164
Place of publication:
Switzerland
Publication date:
2020-10-14
Acceptance date:
2020-10-09
DOI:
EISSN:
1999-4915
Pmid:
33066701

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