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A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion

Abstract:

Glucagon-like peptide-1 (GLP-1) is an endogenous glucose-lowering hormone and GLP-1 receptor agonists are currently being used as antidiabetic drugs clinically. The canonical signalling pathway (including cAMP, Epac2, protein kinase A (PKA) and KATP channels) is almost universally accepted as the main mechanism of GLP-1-stimulated insulin secretion. This belief is based on in vitro studies that used nanomolar (1-100 nM) concentrations of GLP-1. Recently, it was found that the physiological co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00109-017-1508-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Harris Manchester College
Role:
Author
More from this funder
Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Journal of Molecular Medicine Journal website
Volume:
95
Issue:
4
Pages:
361–368
Publication date:
2017-01-17
Acceptance date:
2016-11-30
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
Source identifiers:
672185
Language:
English
Keywords:
Pubs id:
pubs:672185
UUID:
uuid:0d640519-07e1-4da6-b060-9fc9a76f2b20
Local pid:
pubs:672185
Deposit date:
2017-02-21

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