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Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo

Abstract:

Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I alleles are associated with different rates of progression to AIDS, indicating that CTLs play a protective role. Yet virus clearance rates following antiretroviral therapy are not impaired in individuals with advanced HIV disease, suggesting that weake...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pbio.0040090

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Institution:
"University of Oxford", "Imperial College London"
Department:
Department of Immunology
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author
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Institution:
"Harvard School of Public Health, Boston, Massachusetts, USA"
Department:
Departments of Epidemiology and Immunology & Infectious Diseases
Role:
Author
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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
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Funding agency for:
Becca Asquith
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
4
Issue:
4
Pages:
Article: e90
Publication date:
2006-04-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:0d23c811-44a5-4e8f-8dde-4538d01a5fcc
Local pid:
ora:2838
Language:
English
Subjects:

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