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NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations

Abstract:

Recent studies have reported significant advances in the differentiation of human pluripotent stem cells to clinically relevant cell types such as the insulin producing beta-like cells and motor neurons. However, many of the current differentiation protocols lead to heterogeneous cell cultures containing cell types other than the targeted cell fate. Genetically modified human pluripotent stem cells reporting the expression of specific genes are of great value for differentiation protocol opti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.scr.2018.04.010

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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National Institutes of Health More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Research Journal website
Volume:
29
Pages:
220-231
Publication date:
2018-04-23
Acceptance date:
2018-04-21
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Pmid:
29734117
Source identifiers:
848129
Language:
English
Keywords:
Pubs id:
pubs:848129
UUID:
uuid:0c283bea-27ee-409b-8d44-94c1153b9512
Local pid:
pubs:848129
Deposit date:
2018-06-01

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