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Journal article

Homozygosity and risk of childhood death due to invasive bacterial disease.

Abstract:

BACKGROUND: Genetic heterozygosity is increasingly being shown to be a key predictor of fitness in natural populations, both through inbreeding depression, inbred individuals having low heterozygosity, and also through chance linkage between a marker and a gene under balancing selection. One important component of fitness that is often highlighted is resistance to parasites and other pathogens. However, the significance of equivalent loci in human populations remains unclear. Consequently, w...

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Publication status:
Published

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Publisher copy:
10.1186/1471-2350-10-55

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Journal:
BMC medical genetics
Volume:
10
Issue:
1
Pages:
55
Publication date:
2009-01-01
DOI:
EISSN:
1471-2350
ISSN:
1471-2350
Source identifiers:
34756

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