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Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer

Abstract:

Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain mesenchymal properties, such as increased motility. In colorectal cancer, EMT has an important role in tumour progression, metastasis, and drug resistance. There has been accumulating evidence from preclinical and early clinical studies that show that EMT markers might serve as outcome predictors and potential th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1470-2045(21)00343-0

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Oxford college:
Wolfson College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Oncology Journal website
Volume:
22
Issue:
8
Pages:
e358-e368
Publication date:
2021-08-01
Acceptance date:
2021-06-08
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
Language:
English
Keywords:
Pubs id:
1189106
Local pid:
pubs:1189106
Deposit date:
2021-08-05

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