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The effect of sample size on polygenic hazard models for prostate cancer

Abstract:

We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calcula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41431-020-0664-2

Authors


More by this author
Role:
Author
ORCID:
0000-0001-8723-8123
More by this author
Role:
Author
ORCID:
0000-0002-5025-4709
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0003-2294-307X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Oxford college:
Wolfson College
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
28
Issue:
10
Pages:
1467–1475
Publication date:
2020-06-08
Acceptance date:
2020-05-22
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Pmid:
32514134
Language:
English
Keywords:
Pubs id:
1111439
Local pid:
pubs:1111439
Deposit date:
2020-06-22

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