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Drosophila melanogaster as a model to study ciliogenesis

Abstract:

Cilia are microtubule-based extensions of the cell membrane that extend from a mature centriole. Primary (non-motile) cilia are present on most human cells and have important roles in signalling pathways. At the base of the cilium is a selective barrier known as the transition zone (TZ). Defects in the TZ are associated with human congenital diseases such as Meckel-Gruber syndrome (MKS) and Nephronophthisis (NPHP). The TZ is formed by three protein complexes, the MKS, NPHP and Cep290 modules,...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Supervisor
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Funding agency for:
Pratt, M
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:09fa66c3-0be0-424e-a02d-8c72377ebc91
Deposit date:
2017-03-20

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