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A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Abstract:

Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Aust...

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Publication status:
Published

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Publisher copy:
10.1038/ng.424

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Journal:
Nature genetics
Volume:
41
Issue:
9
Pages:
996-1000
Publication date:
2009-09-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:09f64783-3edc-40d8-afe7-2fbc5ea88fa4
Source identifiers:
41343
Local pid:
pubs:41343

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