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High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

Abstract:

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown. We present evidence that lysosomes are intimately associ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep40620

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Oxford college:
University College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Funding agency for:
Aston, D
Grant:
RE/08/004
European Research Council More from this funder
Physiological Society More from this funder
British Heart Foundation More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
40620
Publication date:
2017-01-01
Acceptance date:
2016-12-09
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:671734
UUID:
uuid:09db4ffe-3e7c-4a4b-8d3f-cdaaa99b29de
Local pid:
pubs:671734
Deposit date:
2017-01-23

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