Journal article icon

Journal article

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

Abstract:

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown. We present evidence that lysosomes are intimately associ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/srep40620

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
University College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More from this funder
Funding agency for:
Mirams, G
Burton, R
Grant:
101222/Z/13/Z
109371/Z/15/Z
More from this funder
Funding agency for:
Burton, R
Capel, R
Galione, A
Mirams, G
Grant:
109371/Z/15/Z
109371/Z/15/Z
101222/Z/13/Z
More from this funder
Funding agency for:
Aston, D
Grant:
RE/08/004
Physiological Society More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
40620
Publication date:
2017-01-01
Acceptance date:
2016-12-09
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:671734
UUID:
uuid:09db4ffe-3e7c-4a4b-8d3f-cdaaa99b29de
Local pid:
pubs:671734
Deposit date:
2017-01-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP