Journal article
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.
- Abstract:
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Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown. We present evidence that lysosomes are intimately associ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.2MB)
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- Publisher copy:
- 10.1038/srep40620
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Authors
Funding
European Research Council
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Physiological Society
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British Heart Foundation
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Pages:
- 40620
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-09
- DOI:
- ISSN:
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2045-2322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:671734
- UUID:
-
uuid:09db4ffe-3e7c-4a4b-8d3f-cdaaa99b29de
- Local pid:
- pubs:671734
- Deposit date:
- 2017-01-23
Terms of use
- Copyright holder:
- Capel et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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