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Journal article

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

Abstract:

The retroviral restriction factor tripartite motif-containing 5α (Trim5α) acts during the early postentry stages of the retroviral life cycle to block infection by a broad range of retroviruses, disrupting reverse transcription and integration. The mechanism of this restriction is poorly understood, but it has recently been suggested to involve recruitment of components of the autophagy machinery, including members of the mammalian autophagy-related 8 (ATG8) family involved in targeting prote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.RA118.004202

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0003-0159-9257
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
293
Issue:
47
Pages:
18378-18386
Publication date:
2018-10-03
Acceptance date:
2018-10-03
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
30282803
Source identifiers:
953458
Language:
English
Keywords:
Pubs id:
pubs:953458
UUID:
uuid:091b9027-22f7-4ab9-af38-2661a0309b2f
Local pid:
pubs:953458
Deposit date:
2019-01-08

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