Journal article
A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins
- Abstract:
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The retroviral restriction factor tripartite motif-containing 5α (Trim5α) acts during the early postentry stages of the retroviral life cycle to block infection by a broad range of retroviruses, disrupting reverse transcription and integration. The mechanism of this restriction is poorly understood, but it has recently been suggested to involve recruitment of components of the autophagy machinery, including members of the mammalian autophagy-related 8 (ATG8) family involved in targeting prote...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1074/jbc.RA118.004202
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 293
- Issue:
- 47
- Pages:
- 18378-18386
- Publication date:
- 2018-10-03
- Acceptance date:
- 2018-10-03
- DOI:
- EISSN:
-
1083-351X
- ISSN:
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0021-9258
- Pmid:
-
30282803
- Source identifiers:
-
953458
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:953458
- UUID:
-
uuid:091b9027-22f7-4ab9-af38-2661a0309b2f
- Local pid:
- pubs:953458
- Deposit date:
- 2019-01-08
Terms of use
- Copyright holder:
- Keown et al
- Copyright date:
- 2018
- Notes:
- © 2018 Keown et al. Final version open access under the terms of the Creative Commons CC-BY license.
- Licence:
- CC Attribution (CC BY)
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