Journal article
Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats
- Abstract:
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Rational
Expand abstract
Prepulse inhibition (PPI) is suppression of the startle reflex by a weaker sensory stimulus (prepulse) preceding the startling stimulus. In people with schizophrenia, impairment of attentional modulation of PPI, but not impairment of baseline PPI, is correlated with symptom severity. In rats, both fear conditioning of prepulse and perceptually spatial separation between the conditioned prepulse and a noise masker enhance PPI (the paradigms of attentional modulation of PPI).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1007/s00213-016-4351-5
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Psychopharmacology Journal website
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-06-02
- DOI:
- EISSN:
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1432-2072
- ISSN:
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0033-3158
- Source identifiers:
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632954
Item Description
- Keywords:
- Pubs id:
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pubs:632954
- UUID:
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uuid:07f412b4-c2cb-4ab7-a97b-40c11b27f7dd
- Local pid:
- pubs:632954
- Deposit date:
- 2016-07-09
Terms of use
- Copyright holder:
- Springer-Verlag
- Copyright date:
- 2016
- Notes:
- © Springer-Verlag 2016. This is an open access article. The final version is available online from Springer at: [10.1007/s00213-016-4351-5]
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