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Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure

Abstract:

Low plasma homoarginine (HA) is an emerging biomarker for cardiovascular disease and an independent predictor of mortality in patients with heart failure. Plasma levels appear to reflect cardiac dysfunction, positively correlating with ejection fraction and inversely with circulating brain natriuretic peptide. However, whether this outcome is a bystander or cause-and-effect has yet to be established. Within the context of stroke, a direct causal relationship has been inferred because normal m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/CIRCULATIONAHA.116.025673

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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More from this funder
Grant:
Marie Curie Intra-European Fellowship for Career Development (623127
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Grant:
Ludwig Maximilians-University Munich’s Institutional Strategy LMUexcellent
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Grant:
RG/13/8/30266
FS/11/50/29038
Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
135
Issue:
4
Pages:
400-402
Publication date:
2017-01-23
Acceptance date:
2016-12-15
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
673156
Language:
English
Keywords:
Pubs id:
pubs:673156
UUID:
uuid:077b7829-5cff-478d-b5c3-95f3d52629ff
Local pid:
pubs:673156
Deposit date:
2017-01-27

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