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Thesis

Molecular dissection of ionotropic glutamate receptor delta-family interactions with trans-synaptic proteins

Abstract:

Correct functioning of the brain relies upon the precise connectivity between the billions of neurons that make up this crucial organ. Aberrations in the formation of these elaborate neural networks lead to neurodegenerative and neuropsychiatric disorders. A synapse-spanning molecular triad, involving members of the Neurexin, Cbln and ionotropic glutamate receptor delta families of proteins, is crucial for the accurate formation and proper function of synapses in the cerebellum. This trans...

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Institution:
University of Oxford
Oxford college:
Jesus College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology
Role:
Author

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Supervisor
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Funding agency for:
Jordan Elliott Clay
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:07101578-6cc8-4ba6-99aa-e2a93b49d89d
Local pid:
ora:7564

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