Thesis
Modelling monogenic diabetes mutations using authentic human beta cell models
- Abstract:
-
Genome-wide association studies have identified over 400 loci associated with risk for type 2 diabetes (T2D), a large proportion are associated with pancreatic islet dysfunction. The parallel emergence of genome editing technology such as CRISPR/Cas9, alongside the ability to derive endocrine pancreatic cells from human stem cells, provides unprecedented opportunity to investigate and examine the mechanisms that underpin beta cell dysfunction. Given that several monogenic genes are also as...
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Authors
Contributors
+ Hastoy, B
Role:
Supervisor
+ Gloyn, A
Role:
Supervisor
+ Honoré, C
Role:
Supervisor
+ Hansson, M
Role:
Supervisor
Funding
+ Medical Research Council
More from this funder
Programme:
MRC industrial CASE studentship
Funding agency for:
Duff, C
Grant:
MR/N017919/1
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-03-23
Related Items
Terms of use
- Copyright holder:
- Duff, C
- Copyright date:
- 2020
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