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Thesis

Modelling monogenic diabetes mutations using authentic human beta cell models

Abstract:

Genome-wide association studies have identified over 400 loci associated with risk for type 2 diabetes (T2D), a large proportion are associated with pancreatic islet dysfunction. The parallel emergence of genome editing technology such as CRISPR/Cas9, alongside the ability to derive endocrine pancreatic cells from human stem cells, provides unprecedented opportunity to investigate and examine the mechanisms that underpin beta cell dysfunction. Given that several monogenic genes are also as...

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Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Harris Manchester College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Programme:
MRC industrial CASE studentship
Funding agency for:
Duff, C
Grant:
MR/N017919/1
More from this funder
Funding agency for:
Duff, C
Grant:
R30536_CN002
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-03-23

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