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Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy

Abstract:

Both NOD1/CARD4 and NOD2/CARD15 are intracellular pattern-recognition receptors involved in the innate immune response. Germline NOD2/CARD15 variation has a definite effect on susceptibility to Crohn's disease (CD) and phenotype, although this contribution is weak in Scotland and Scandinavia. The NOD1/CARD4 gene lies within the putative inflammatory bowel disease (IBD) locus at 7p14.3. We have assessed, in detail, the influence of germline NOD1/CARD4 variation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddm169

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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
16
Issue:
18
Pages:
2175-2186
Publication date:
2007-07-05
Acceptance date:
2007-06-28
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
17613538
Source identifiers:
827888
Language:
English
Keywords:
Pubs id:
pubs:827888
UUID:
uuid:0670a211-d684-45c3-b3f8-61aebe4fdaff
Local pid:
pubs:827888
Deposit date:
2018-08-09

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