Journal article
Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci
- Abstract:
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As a result of technological and analytical advances, genome-wide characterization of key epigenetic alterations is now feasible in complex diseases. We hypothesized that this may provide important insights into gene-environmental interactions in Crohn's disease (CD) and is especially pertinent to early onset disease.The Illumina 450K platform was applied to assess epigenome-wide methylation profiles in circulating leukocyte DNA in discovery and replication pediatric CD cohorts and controls. ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Version of record, pdf, 914.6KB)
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- Publisher copy:
- 10.1097/MIB.0000000000000179
Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Inflammatory Bowel Diseases Journal website
- Volume:
- 20
- Issue:
- 10
- Pages:
- 1784–1793
- Publication date:
- 2014-08-20
- Acceptance date:
- 2014-07-08
- DOI:
- EISSN:
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1536-4844
- ISSN:
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1078-0998
- Pmid:
-
25144570
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:827882
- UUID:
-
uuid:06706b9d-62ef-4e19-b122-54b4a6855f77
- Local pid:
- pubs:827882
- Source identifiers:
-
827882
- Deposit date:
- 2018-08-09
Terms of use
- Copyright holder:
- Adams et al
- Copyright date:
- 2014
- Notes:
- © 2014 Crohn's and Colitis Foundation of America, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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