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Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci

Abstract:

As a result of technological and analytical advances, genome-wide characterization of key epigenetic alterations is now feasible in complex diseases. We hypothesized that this may provide important insights into gene-environmental interactions in Crohn's disease (CD) and is especially pertinent to early onset disease.The Illumina 450K platform was applied to assess epigenome-wide methylation profiles in circulating leukocyte DNA in discovery and replication pediatric CD cohorts and controls. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/MIB.0000000000000179

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Role:
Author
ORCID:
0000-0003-4368-1961
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Role:
Author
ORCID:
0000-0002-3944-6646
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Role:
Author
ORCID:
0000-0001-8182-2812
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Publisher:
Oxford University Press Publisher's website
Journal:
Inflammatory Bowel Diseases Journal website
Volume:
20
Issue:
10
Pages:
1784–1793
Publication date:
2014-08-20
Acceptance date:
2014-07-08
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
Pmid:
25144570
Source identifiers:
827882
Language:
English
Keywords:
Pubs id:
pubs:827882
UUID:
uuid:06706b9d-62ef-4e19-b122-54b4a6855f77
Local pid:
pubs:827882
Deposit date:
2018-08-09

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