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Journal article

Intrathecal B cell activation in LGI1-antibody encephalitis

Abstract:

Objective:
To study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a peripherally initiated immune response. However, it is unknown whether B cells within the CNS contribute to the ongoing pathogenesis of LGI1 antibody encephalitis.


Methods:
Paired CSF ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1212/NXI.0000000000000669

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
St Hilda's College
Role:
Author
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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Neurology, Neuroimmunology and Neuroinflammation Journal website
Volume:
7
Issue:
2
Article number:
e669
Publication date:
2020-02-06
Acceptance date:
2019-12-24
DOI:
EISSN:
2332-7812
Source identifiers:
1079566
Language:
English
Keywords:
Pubs id:
pubs:1079566
UUID:
uuid:04c651ef-cf6d-4539-8ad5-747b9e1e5204
Local pid:
pubs:1079566
Deposit date:
2019-12-24

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