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Hierarchical natural move Monte Carlo refines flexible RNA structures into cryo-EM densities

Abstract:

Ribonucleic acids (RNAs) play essential roles in living cells. Many of them fold into defined three-dimensional (3D) structures to perform functions. Recent advances in single-particle cryo-electron microscopy (cryo-EM) have enabled structure determinations of RNA to atomic resolutions. However, most RNA molecules are structurally flexible, limiting the resolution of their structures solved by cryo-EM. In modeling these molecules, several computational methods are limited by the requirement o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1261/rna.071100.119

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Role:
Author
ORCID:
0000-0003-3475-4508
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Role:
Author
ORCID:
0000-0002-8234-1997
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
RNA Journal website
Volume:
26
Pages:
1755-1766
Publication date:
2020-08-21
Acceptance date:
2020-08-15
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
Pmid:
32826323
Pubs id:
1129785
Local pid:
pubs:1129785
Language:
English
Keywords:
Format:
Print-Electronic

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