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Identification, preclinical profile, and clinical proof of concept of a novel palindromic orally bio-available pro-drug of miridesap

Abstract:

Background and Purpose: Miridesap depletes serum amyloid P component (SAP) and forms a component of a novel approach to remove systemic amyloid deposits; low oral bioavailability necessitates parenteral administration. We sought to identify a pro-drug that preserves the pharmacological properties of miridesap while having adequate oral bioavailability and physical stability. The pharmacology of palindromic miridesap is unique; previous pro-drug efforts did not progress to ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/bph.14956

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Institution:
University of Oxford
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-8093-7084
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University Of Oxford More from this funder
Publisher:
Wiley Publisher's website
Journal:
British Journal of Pharmacology Journal website
Volume:
177
Issue:
8
Pages:
1853-1864
Publication date:
2020-02-11
Acceptance date:
2019-11-27
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Source identifiers:
1075888
Language:
English
Keywords:
Pubs id:
pubs:1075888
UUID:
uuid:025c2db0-4028-42c0-8d0a-b280cff821a4
Local pid:
pubs:1075888
Deposit date:
2019-12-02

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