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Thesis

Characterisation of cello: an ENU-induced mouse model of early-onset hearing loss

Abstract:

cello is a recessive mouse model of early-onset, sensorineural hearing loss that was identified from a large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis screen undertaken at MRC Harwell. Linkage analysis and whole-genome sequencing identified that cello mice have a non-synonymous point mutation in Ikaros family zinc finger 2 (Ikzf2), which encodes a zinc finger transcription factor called helios.

To investigate the role of heli...

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Department:
University of Oxford
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Author

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Department:
MRC Harwell
Role:
Supervisor
Department:
MRC Harwell
Role:
Supervisor
Department:
Biochemistry, University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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