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A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Abstract:

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddz070

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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
28
Issue:
15
Pages:
2615–2633
Publication date:
2019-04-10
Acceptance date:
2019-03-26
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
31127295
Source identifiers:
1003537
Language:
English
Keywords:
Pubs id:
pubs:1003537
UUID:
uuid:002a3e55-b9cb-4d8f-9685-befe87041eba
Local pid:
pubs:1003537
Deposit date:
2019-06-10

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