Journal article
A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
- Abstract:
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Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 679.4KB)
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- Publisher copy:
- 10.1093/hmg/ddz070
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human Molecular Genetics Journal website
- Volume:
- 28
- Issue:
- 15
- Pages:
- 2615–2633
- Publication date:
- 2019-04-10
- Acceptance date:
- 2019-03-26
- DOI:
- EISSN:
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1460-2083
- ISSN:
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0964-6906
- Pmid:
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31127295
- Source identifiers:
-
1003537
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1003537
- UUID:
-
uuid:002a3e55-b9cb-4d8f-9685-befe87041eba
- Local pid:
- pubs:1003537
- Deposit date:
- 2019-06-10
Terms of use
- Copyright holder:
- Sung et al.
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Published by Oxford University Press. This is the accepted manuscript version of the article. The final version is available online from Oxford University Press at https://doi.org/10.1093/hmg/ddz070
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