Blockade of GABA(B) receptors alters the tangential migration of cortical neurons.
|Abstract||To better understand the role of neurotransmitter receptors in neuronal differentiation and maturation a detailed knowledge of their identity, location and function in the plasma membrane of specific neuronal populations during development is required. Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain slice cultures we show that virtually all neurons (approximately 98%) migrating through the lower intermediate zone ... [truncated at 450 characters in length]|
|Author||López-Bendito, G; Luján, R; Shigemoto, R; et al|
|Key phrase||Animals Baclofen Benzylamines Cell Movement Cerebral Cortex Cerebral Ventricles Culture Techniques Dose-Response Relationship, Drug Electrophysiology GABA Agonists GABA Antagonists GABA-B Receptor Antagonists Immunohistochemistry Neurons Phosphinic Acids Rats Rats, Wistar Receptors, GABA-B|
Near-infrared spectroscopy and spectral mapping of Jupiter and the Galilean satellites: results from Galileo's initial orbit.
|Abstract||The Near Infrared Mapping Spectrometer performed spectral studies of Jupiter and the Galilean satellites during the June 1996 perijove pass of the Galileo spacecraft. Spectra for a 5-micrometer hot spot on Jupiter are consistent with the absence of a significant water cloud above 8 bars and with a depletion of water compared to that predicted for solar composition, corroborating results from the Galileo probe. Great Red Spot (GRS) spectral images ... [truncated at 450 characters in length]|
|Author||Carlson, R; Smythe, W; Baines, K; et al|
|Key phrase||Ammonia Carbon Dioxide Extraterrestrial Environment Hydroxides Jupiter Methane Phosphines Spectroscopy, Near-Infrared Water|
GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells.
|Abstract||Feedforward inhibition of neurons is a fundamental component of information flow control in the brain. We studied the roles played by neurogliaform cells (NGFCs) of stratum lacunosum moleculare of the hippocampus in providing feedforward inhibition to CA1 pyramidal cells. We recorded from synaptically coupled pairs of anatomically identified NGFCs and CA1 pyramidal cells and found that, strikingly, a single presynaptic action potential evoked a b ... [truncated at 450 characters in length]|
|Author||Price, CJ; Scott, R; Rusakov, DA; et al|
|Key phrase||Action Potentials Animals Baclofen Calcium Calcium Signaling GABA Agonists GABA Antagonists Hippocampus Inhibitory Postsynaptic Potentials Interneurons Neural Inhibition Neural Pathways Neuroglia Organ Culture Techniques Phosphinic Acids Propanolamines Pyramidal Cells Rats Receptors, GABA-A Receptors, GABA-B Synaptic Transmission gamma-Aminobutyric Acid|
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
|Abstract||Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain disorders. So far, allosteric modulators are the only subtype selective ligands, but pure agonists still have strong therapeutic potential. Here, we aimed at investigating the possibility of developing subtype-selective agonists by extending the glutamate-like structure to hit a nonconsensus binding area. We report the properties of the first mGlu4-selective ort ... [truncated at 450 characters in length]|
|Author||Goudet, C; Vilar, B; Courtiol, T; et al|
|Key phrase||Animals Antiparkinson Agents Binding Sites Dose-Response Relationship, Drug Excitatory Amino Acid Agonists HEK293 Cells Humans Ligands Male Mice Mice, Knockout Molecular Structure Mutagenesis, Site-Directed Patch-Clamp Techniques Phosphinic Acids Rats Rats, Wistar Receptors, Metabotropic Glutamate Recombinant Proteins Structure-Activity Relationship Synaptic Transmission|
Small molecule activation by frustrated Lewis pairs.
|Abstract||A series of frustrated Lewis pairs (FLPs) based on the Lewis acids tris(perchloroaryl)borane (BAr(Cl)), and tris(2,2',2''-perfluorobiphenyl)borane (PBB) and trialkylphosphines were prepared; their ability to effect the heterolytic cleavage of dihydrogen, insert carbon dioxide into the borohydride, and reduce the resulting formatoborate to methanol were studied. Additionally, the insertion of CO(2) into a B-OH bond is explored with the ultimate ai ... [truncated at 450 characters in length]|
|Author||Travis, AL; Binding, SC; Zaher, H; et al|
|Key phrase||Boranes Crystallography, X-Ray Lewis Acids Models, Molecular Molecular Structure Phosphines|