Inositol phosphates play a fundamental role in many intracellular processes. Of particular importance is the role of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in the protein kinase B (PKB/Akt) signalling pathway. PtdIns(3,4,5)P3 recruits PKB to the cell membrane through binding interactions with its pleckstrin homology (PH) domain. In several human cancers, this signalling pathway is upregulated, resulting in increased cell gr ... [truncated at 450 characters in length]
|Key phrase||Inositol Inositol Phosphate Inositol Pyrophosphate Protein Kinase B Organic Synthesis|
Chapter 1 is a brief literature review of the most recent progress in the area of C-H functionalization via palladium catalysis. This covers the functionalization of electron deficient arenes and heterocycles with alkenyl and alkyl halides both using inter- and intra-molecular reactions. The chapter also contains an overview of recent work from the Willis group.
Chapter 2 presents the functionalization of electron deficient arenes and al ... [truncated at 450 characters in length]
|Key phrase||organic chemistry palladium-catalysis organic synthesis heterocycles|
This thesis is concerned with investigations into applications of double asymmetric induction and parallel kinetic resolution in asymmetric synthesis.
Chapter 1 introduces enantiorecognition phenomena as a significant field in asymmetric synthesis. The main approaches in this field are described: double asymmetric induction, kinetic resolution, parallel kinetic resolution and dynamic kinetic resolution.
Chapter 2 describes investig ... [truncated at 450 characters in length]
|Key phrase||Organic synthesis|