Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
|Abstract||Loss of iRhom2, a catalytically inactive rhomboid-like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2-null mice appear normal: they do not show the several defects seen in TACE knockouts, suggesting that TACE maturation is independent of iRhom2 in cells other than macrophages. Here we show that the physiological ... [truncated at 450 characters in length]|
|Author||Christova, Y; Adrain, C; Bambrough, P; et al|
|Key phrase||iRhom TACE ADAM17 membrane trafficking|
Mutational analysis of membrane traffic in Arabidopsis thaliana
|Abstract||To identify novel and essential components of the plant membrane trafficking mechanisms, Arabidopsis membrane trafficking mutants from fluorescent protein-based forward genetic screens were characterized. First, four novel glutathione synthase (GSH2) mutant alleles featured swollen endoplasmic reticulum (ER)-derived bodies that accumulated a soluble secretory marker. Consistent with the role of GSH2 in glutathione biosynthesis, ... [truncated at 450 characters in length]|
|Creator||Kin Cheong Kenneth Au;|
|Key phrase||membrane trafficking forward genetics Arabidopsis thaliana|