|Abstract||A comparative study of seven crystallographically characterized rhodium precatalysts, which contain a variety of chelating diphosphine ligands, for the hydroacylation of 1-octyne or 1-octene with 2-(methylthio)benzaldehyde has been undertaken. These studies show that the best performing catalyst for 1-octyne, [Rh(L)(η-CHF)][BAr ], L = PrPNMePPr, delivers alkyne selective hydroacylation with high efficiencies at low loadings (1 mol %, 2.0 M aldehy ... [truncated at 450 characters in length]|
|Author||Pernik, I; Hooper, JF; Chaplin, AB; et al|
|Key phrase||hydroacylation rhodium alkyne alkene diphosphine|
Chapter 1 is an overview of the key developments in rhodium-catalysed hydroacylation. The main focus of this chapter is the use of various chelation strategies for the stabilisation of key rhodium-acyl intermediates. In addition, the more recent emergence of regioselective hydroacylation processes has been highlighted.
Chapter 2 discloses the branched-selective intermolecular hydroacylation of 1,3-dienes and S-chelating aldehydes to aff ... [truncated at 450 characters in length]
|Key phrase||rhodium selectivity regioselectivity hydroacylation catalysis|
The functionalisation of C-H bonds has been widely studied in organic synthesis. This work presents the results of investigation into two areas of current research, copper-catalysed aromatic C-H functionalisation and rhodium-catalysed hydroacylation. Chapter 1 presents the development of palladium- and copper-catalysed aromatic C-H functionalisation with particular attention paid to regiocontrol. Chapter 2 describes the development of copper-c ... [truncated at 450 characters in length]
|Creator||Fiona Rosemary Truscott;|
|Key phrase||copper rhodium cross coupling hydroacylation C-C bond formation C-H functionalisation|
This work describes the extension of rhodium-catalysed intermolecular hydroacylation to encompass some tandem catalytic processes, wherein a further catalytic process is enacted on the product of an intermolecular hydroacylation reaction in “one pot”.
Chapter 1 entails an overview of the development of hydroacylation chemistry, with a focus on the different types of catalytic systems which have been used to facilitate this transformation ... [truncated at 450 characters in length]
|Key phrase||chemistry catalysis heterocycles rhodium hydroacylation|
|Author||González-Rodríguez, C; Parsons, SR; Thompson, AL; et al|
|Key phrase||homogeneous catalysis hydroacylation ketones kinetic resolution rhodium|