Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.
|Abstract||To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents.|
|Author||Barker, A; Sharp, SJ; Timpson, NJ; et al|
|Key phrase||Adenylate Cyclase Adolescent Blood Glucose Child Cryptochromes Fasting Female Genetic Loci Genome-Wide Association Study Glucose Transporter Type 2 Glucose-6-Phosphatase Homeodomain Proteins Humans Male Polymorphism, Single Nucleotide Protein-Serine-Threonine Kinases Transcription Factors Tumor Suppressor Proteins|
Differential confounding of rare and common variants in spatially structured populations.
|Abstract||Well-powered genome-wide association studies, now made possible through advances in technology and large-scale collaborative projects, promise to characterize the contribution of rare variants to complex traits and disease. However, while population structure is a known confounder of association studies, it remains unknown whether methods developed to control stratification are equally effective for rare variants. Here, we demonstrate that rare v ... [truncated at 450 characters in length]|
|Author||Mathieson, I; McVean, G;|
|Key phrase||Data Interpretation, Statistical Gene Frequency Genetic Variation Genetics, Population Genome-Wide Association Study Geography Humans Phenotype Quantitative Trait, Heritable Risk Assessment|
Common variants at 12q15 and 12q24 are associated with infant head circumference.
|Abstract||To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associ ... [truncated at 450 characters in length]|
|Author||Taal, HR; St Pourcain, B; Thiering, E; et al|
|Key phrase||Chromosomes, Human, Pair 12 European Continental Ancestry Group Female Genetic Loci Genetic Markers Genome-Wide Association Study Head Humans Infant Male Meta-Analysis as Topic Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications|
Will the real disease gene please stand up?
|Abstract||A common dilemma arising in linkage studies of complex genetic diseases is the selection of positive signals, their follow-up with association studies and discrimination between true and false positive results. Several strategies for overcoming these issues have been devised. Using the Genetic Analysis Workshop 14 simulated dataset, we aimed to apply different analytical approaches and evaluate their performance in discerning real associations. W ... [truncated at 450 characters in length]|
|Author||Shephard, N; John, S; Cardon, L; et al|
|Key phrase||Chromosome Mapping Disease Genetics, Population Genome-Wide Association Study Haplotypes Humans Reproducibility of Results Sample Size|
What will genome-wide association studies mean to the clinical endocrinologist?
|Key phrase||Endocrine System Diseases Endocrinology Genetic Linkage Genetic Predisposition to Disease Genetics, Population Genome-Wide Association Study Humans|