Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.
|Abstract||Reporter transgenes were introduced into the type 1 tight-skin (Tsk1/+) mouse model of scleroderma to test the hypothesis that fibroblast-specific genetic programs are activated in fibrosis.|
|Author||Denton, CP; Zheng, B; Shiwen, X; et al|
|Key phrase||Animals Disease Models, Animal Enhancer Elements, Genetic Fibroblasts Gene Expression Regulation Mice Mice, Transgenic Procollagen Scleroderma, Systemic|
|Abstract||Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI.|
|Author||Grunwald, IQ; Kühn, AL; Backens, M; et al|
|Key phrase||Brain Humans Image Enhancement Multiple Sclerosis Nerve Fibers, Myelinated Spinal Cord|
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
|Abstract||The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in the major vasculature of the mouse embryo. As a pivotal factor in HSC ontogeny, its transcriptional regulation is of high interest but is largely undefined. In this study, we used a combination of comparative genomics and chromatin analysis to identify a highly cons ... [truncated at 450 characters in length]|
|Author||Nottingham, WT; Jarratt, A; Burgess, M; et al|
|Key phrase||Adaptor Proteins, Signal Transducing Animals Basic Helix-Loop-Helix Transcription Factors Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins Embryo, Mammalian Enhancer Elements, Genetic GATA2 Transcription Factor Hematopoietic Stem Cells LIM Domain Proteins Metalloproteins Mice Multiprotein Complexes Proto-Oncogene Protein c-ets-1 Proto-Oncogene Proteins Transcription, Genetic|
Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers.
|Abstract||Gene regulation through cis-regulatory elements plays a crucial role in development and disease. A major aim of the post-genomic era is to be able to read the function of cis-regulatory elements through scrutiny of their DNA sequence. Whilst comparative genomics approaches have identified thousands of putative regulatory elements, our knowledge of their mechanism of action is poor and very little progress has been made in systematically de-coding ... [truncated at 450 characters in length]|
|Author||Parker, HJ; Piccinelli, P; Sauka-Spengler, T; et al|
|Key phrase||Animals Enhancer Elements, Genetic Genes, Homeobox Vertebrates|
The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
|Abstract||The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to the first emerging HSCs of the mouse embryo when linked to the heterologous hsp68 promoter. Endogenous Runx1 is transcribed from 2 alternative promoters ... [truncated at 450 characters in length]|
|Author||Bee, T; Ashley, EL; Bickley, SR; et al|
|Key phrase||Animals Core Binding Factor Alpha 2 Subunit Embryo, Mammalian Enhancer Elements, Genetic Hematopoietic Stem Cells Mice Mice, Transgenic Promoter Regions, Genetic Species Specificity Transcription, Genetic|