Modelling the role of angiogenesis and vasculogenesis in solid tumour growth.
|Abstract||Recent experimental evidence suggests that vasculogenesis may play an important role in tumour vascularisation. While angiogenesis involves the proliferation and migration of endothelial cells (ECs) in pre-existing vessels, vasculogenesis involves the mobilisation of bone-marrow-derived endothelial progenitor cells (EPCs) into the bloodstream. Once blood-borne, EPCs home in on the tumour site, where subsequently they may differentiate into ECs an ... [truncated at 450 characters in length]|
|Author||Stamper, IJ; Byrne, HM; Owen, MR; et al|
|Key phrase||Animals Endothelial Cells Mathematics Models, Biological Neoplasms, Experimental Neoplastic Stem Cells Neovascularization, Pathologic Nonlinear Dynamics|
The structural characteristics of nonspecific lipid transfer proteins explain their resistance to gastroduodenal proteolysis.
|Abstract||The structure and stability of the allergenic nonspecific lipid transfer protein (LTP) of peach were compared with the homologous LTP1 of barley and its liganded form LTP1b. All three proteins were resistant to gastric pepsinolysis and were only slowly digested at 1 to 2 out of 14 potential tryptic and chymotryptic cleavage sites under duodenal conditions. Peach LTP was initially cleaved at Tyr79-Lys80 and then at Arg39-Thr40 (a site lost in barl ... [truncated at 450 characters in length]|
|Author||Wijesinha-Bettoni, R; Alexeev, Y; Johnson, P; et al|
|Key phrase||Amino Acid Sequence Antigens, Plant Carrier Proteins Duodenum Hordeum Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy Molecular Dynamics Simulation Molecular Sequence Data Plant Proteins Protein Conformation Protein Folding Prunus Sequence Homology, Amino Acid Stomach|
Modeling resistance to genetic control of insects.
|Abstract||The sterile insect technique is an area-wide pest control method that reduces pest populations by releasing mass-reared sterile insects which compete for mates with wild insects. Modern molecular tools have created possibilities for improving and extending the sterile insect technique. As with any new insect control method, questions arise about potential resistance. Genetic RIDL(®)(1) (Release of Insects carrying a Dominant Lethal) technology is ... [truncated at 450 characters in length]|
|Author||Alphey, N; Bonsall, MB; Alphey, L;|
|Key phrase||Algorithms Animals Animals, Genetically Modified Computer Simulation Gene Frequency Genes, Dominant Genes, Insect Genes, Lethal Genetic Fitness Genetics, Population Homozygote Insects Models, Genetic Pest Control, Biological Population Dynamics|
APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model.
|Abstract||The APOE genotype predicts the age at onset of Alzheimer disease (AD) and neuropathologic progression. However, studies relating APOE alleles to the rate of cognitive decline have been inconclusive. This may stem from their use of linear statistical analyses.|
|Author||Martins, CA; Oulhaj, A; de Jager, CA; et al|
|Key phrase||Aged Aged, 80 and over Alzheimer Disease Apolipoprotein E2 Apolipoprotein E4 Apolipoproteins E Cognition Disorders Disease Progression Female Gene Dosage Gene Frequency Genetic Testing Genotype Heterozygote Homozygote Humans Male Neuropsychological Tests Nonlinear Dynamics Polymorphism, Genetic Predictive Value of Tests Prognosis|
Polarization effects in ionic solids and melts
|Abstract||Ionic solids and melts are compounds in which the interactions are dominated by electrostatic effects. However, the polarization of the ions also plays an important role in many respects as has been clarified in recent years thanks to the development of realistic polarizable interaction potentials. After detailing these models, we illustrate the importance of polarization effects on a series of examples concerning the structural properties, such ... [truncated at 450 characters in length]|
|Author||Salanne, M; Madden, PA;|
|Key phrase||ionic compounds molten salts polarization molecular dynamics|