This thesis is concerned with the development of methodology for the asymmetric synthesis of a range of amino polyol containing compounds.
Chapter 1 highlights the abundance of the amino polyol motif in nature, the wide range of biological activities displayed by amino polyol containing compounds, and their occurrence in drug molecules. A variety of different methods for the synthesis of stereodefined amino polyols is then discussed.
|Creator||Emma Marie Foster;|
This thesis is concerned with the application of the conjugate addition of functionalised lithium amides in the asymmetric syntheses of (−)-morphine and all members of the homalium alkaloids. Chapter 1 introduces the conjugate addition reaction as an important bond forming reaction, and explores its utility in the asymmetric synthesis of a variety of natural products. The conjugate addition of secondary lithium amides derived from α-methylbenz ... [truncated at 450 characters in length]
|Creator||James A. Lee;|
This thesis is concerned with the asymmetric conjugate addition reactions of a range of chiral nucloeophiles.
Chapter 1 introduces the conjugate addition reaction as a valuable carbon-carbon and carbon-heteroatom bond forming reaction in organic chemistry, and explores the asymmet- ric conjugate addition of a range of chiral and achiral carbon and nitrogen nucleophiles to a range of acceptors.
Chapter 2 explores the use of the N-be ... [truncated at 450 characters in length]
|Creator||Scott Alexander Bentley;|
This thesis describes investigations into the utility of boron fluorides and tetrafluoroborates as sources of nucleophilic fluorine.
Chapter 1 discusses the history and importance of the field of organofluorine chemistry and outlines some of the principle motivations for the site-selective fluorination of organic molecules. Some of the most commonly useed methods of nucleophilic fluorination are briefly surveyed, with an emphasis on the ... [truncated at 450 characters in length]
|Creator||Alex Cresswell; Morris Melloney;|
|Abstract||Dr adhesins are expressed on the surface of uropathogenic and diffusely adherent strains of Escherichia coli. The major ashesin subunit (DraE/AfaE) of these organelles mediates attachment of the bacterium to the surface of the host cell and possibly intracellular invasion through its recognition of the complement regulator decay-accelerating factor (DAF) and/or members of the carcinoembryonic antigen (CEA) family. The adhesin subunit of ... [truncated at 450 characters in length]|
|Author||David M. Pettigrew; Pietro Roversi; Stephen G. Davies; et al|