Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
|Abstract||The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is considerable new knowledge about how BPs work. Their classical pharmacological effects appear to result from two key properties: their affinity for bone mineral and their inhibitory effects on osteoclasts. Mineral binding affinities differ ... [truncated at 450 characters in length]|
|Author||Russell, R Graham G; Xia, Zhidao; Dunford, James E; et al|
|Subject||Animals Bone Neoplasms Bone Resorption Bone and Bones Diphosphonates Guanosine Triphosphate Humans Models, Biological Models, Chemical Multiple Myeloma Neoplasm Metastasis Nitrogen Osteoclasts Osteocytes Osteoporosis Protein Processing, Post-Translational T-Lymphocytes Treatment Outcome secondary metabolism chemistry pharmacology therapeutic use chemistry metabolism chemistry metabolism metabolism therapy metabolism|
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.
|Abstract||The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology. Whereas elevated levels of PIM1 and PIM2 were mostly found in hematologic malignancies and prostate cancer, increased PIM3 expression was observed in different solid tumors. PIM kinases are constitutively active and their activity supports in vitro an ... [truncated at 450 characters in length]|
|Author||Brault, Laurent; Gasser, Christelle; Bracher, Franz; et al|
|Subject||Amino Acid Sequence Animals Hematologic Neoplasms Humans Molecular Sequence Data Neoplasms Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-pim-1 enzymology genetics therapy enzymology genetics therapy antagonists and inhibitors chemistry genetics antagonists and inhibitors chemistry genetics antagonists and inhibitors chemistry genetics|