The centaurin gamma-1 GTPase-like domain functions as an NTPase.
|Abstract||Centaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding studies, we show that, for C ... [truncated at 450 characters in length]|
|Author||Soundararajan, Meera; Yang, Xiaowen; Elkins, Jonathan M; et al|
|Subject||Amino Acid Sequence Binding Sites Cloning, Molecular Escherichia coli GTP-Binding Proteins GTPase-Activating Proteins Hydrolysis Models, Molecular Molecular Structure Nucleoside-Triphosphatase Nucleotides Protein Structure, Tertiary Signal Transduction Substrate Specificity ras Proteins metabolism chemistry metabolism chemistry metabolism chemistry metabolism metabolism chemistry metabolism|
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
|Abstract||Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Galpha GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specif ... [truncated at 450 characters in length]|
|Author||Willard, Francis S; Willard, Melinda D; Kimple, Adam J; et al|
|Subject||Animals Binding Sites Cell Differentiation Extracellular Signal-Regulated MAP Kinases Fibroblast Growth Factor 2 Humans Mice Mitogen-Activated Protein Kinases Multiprotein Complexes Nerve Growth Factor Neurites PC12 Cells Protein Binding RGS Proteins Rats raf Kinases ras Proteins antagonists and inhibitors physiology antagonists and inhibitors physiology physiology metabolism|