Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
|Abstract||Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Galpha GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specif ... [truncated at 450 characters in length]|
|Author||Willard, Francis S; Willard, Melinda D; Kimple, Adam J; et al|
|Subject||Animals Binding Sites Cell Differentiation Extracellular Signal-Regulated MAP Kinases Fibroblast Growth Factor 2 Humans Mice Mitogen-Activated Protein Kinases Multiprotein Complexes Nerve Growth Factor Neurites PC12 Cells Protein Binding RGS Proteins Rats raf Kinases ras Proteins antagonists and inhibitors physiology antagonists and inhibitors physiology physiology metabolism|