UnPAKing the class differences among p21-activated kinases.
|Abstract||The p21-activated kinases (PAKs) are signal transducers, central to many vital cellular processes, including cell morphology, motility, survival, gene transcription and hormone signalling. The mammalian PAK family contains six serine/threonine kinases divided into two subgroups, group I (PAK 1-3) and group II (PAK4-6), based on their domain architecture and regulation. PAKs functioning as dynamic signalling nodes present themselves as attractive ... [truncated at 450 characters in length]|
|Author||Eswaran, Jeyanthy; Soundararajan, Meera; Kumar, Rakesh; et al|
|Subject||Catalysis Signal Transduction Substrate Specificity p21-Activated Kinases metabolism|
Targeting group II PAKs in cancer and metastasis.
|Abstract||The p21 activated kinases (PAKs) play an essential role in cell signaling and control a variety of cellular functions including cell motility, survival, angiogenesis and mitosis. PAKs are important regulators in growth factor signaling, cytoskeletal reorganization and growth factor-mediated cell migration. Overexpression of PAKs has been detected in many cancers and linked to increased migration potential, anchorage independent growth and metasta ... [truncated at 450 characters in length]|
|Author||Eswaran, Jeyanthy; Soundararajan, Meera; Knapp, Stefan;|
|Subject||Animals Antineoplastic Agents Apoptosis Cell Transformation, Neoplastic Chemistry, Pharmaceutical Crystallography, X-Ray Cytoskeleton Drug Design Gene Expression Regulation, Neoplastic Humans Mitosis Neoplasm Metastasis Neoplasms Neurons p21-Activated Kinases pharmacology methods methods metabolism metabolism pathology metabolism metabolism|