UDP-glucose dehydrogenase: structure and function of a potential drug target.
|Abstract||Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in the present paper, and structure-based sequence comparison is used for subclassification of UGDH family members. The eukaryotic group of enzymes (UGDH-II) ... [truncated at 450 characters in length]|
|Author||Egger, Sigrid; Chaikuad, Apirat; Kavanagh, Kathryn L; et al|
|Subject||Animals Enzyme Inhibitors Humans Hyaluronic Acid Neoplasms Uridine Diphosphate Glucose Dehydrogenase Uridine Diphosphate Glucuronic Acid therapeutic use metabolism drug therapy metabolism antagonists and inhibitors chemistry genetics metabolism metabolism|