Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
|Abstract||p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all active, monophosphorylated group II catalytic domains revealed a surprising degree of domain plasticity, including a number of catalytically productive an ... [truncated at 450 characters in length]|
|Author||Eswaran, Jeyanthy; Lee, Wen Hwa; Debreczeni, Judit E; et al|
|Subject||Amino Acid Sequence Animals Catalytic Domain Crystallography Molecular Sequence Data Protein Conformation Protein Kinase Inhibitors Protein-Serine-Threonine Kinases Purines drug effects genetics chemistry pharmacology antagonists and inhibitors chemistry genetics chemistry|