D-amino acid oxidase (DAO) is a flavin-dependent enzyme that is expressed in the mammalian brain. It is the metabolising enzyme of several D-amino acids, including D serine, which is an endogenous agonist at the glycine co-agonist site of the glutamatergic NMDA receptor. As such, regulation of D serine levels in the brain by DAO may indirectly modulate the activity of NMDA receptors. The expression and activity of DAO have been reported to be ... [truncated at 450 characters in length]
|Creator||Jill Frances Betts;|
|Subject||Medical Sciences Neuroscience Neuropathology Psychiatry Molecular neuropathology Psychopharmacology Psychotic illness|
The development of predictive biomarkers in neuroscience is increasingly enabling bioprediction of adverse behavioural events, from psychosis to impulsive violent reaction. Because many brain-based disorders can be thought of as end-states of a long development, bioprediction carries immense therapeutic potential.
In this thesis, I analyse issues raised by the development of bioprediction of brain-based disorder. I argue that ethical an ... [truncated at 450 characters in length]
|Creator||Matthew L Baum;|
|Subject||Medical Sciences Psychiatry Neuroscience Molecular neuropathology Psychotic illness Neurology Ethics (Moral philosophy) Ethics of the biosciences Practical ethics Criminology ? Sentencing and Punishment Public Health|
Schizophrenia and bipolar disorder are chronic and devastating disorders affecting 1% of the population worldwide. They have the same prevalence in both sexes, although it is well accepted that schizophrenic men present an earlier age of onset, higher prevalence of negative symptoms and poorer prognosis. With the advent of neuroimaging techniques such as computed tomography scans and magnetic resonance imaging (MRI), it has been possible to di ... [truncated at 450 characters in length]
|Creator||Pablo F. Paez Rodriguez ;|
|Subject||Psychiatry Bipolar disorder Psychotic illness Neuropsychology|
Objective: To investigate whether the mortality gap has reduced in recent years between people with schizophrenia or bipolar disorder and the general population.
Design: Record linkage study.
Setting: English hospital episode statistics and death registration data for patients discharged 1999-2006.
Participants: People discharged from inpatient care with a diagnosis of schizophrenia or bipolar disorder, followed for a year af ... [truncated at 450 characters in length]
|Author||Robert Stewart; Michael J. Goldacre;|
|Subject||Psychiatry Bipolar disorder Psychotic illness|