|Abstract||Bipolar disorder is a psychiatric condition characterized by episodes of elevated mood interspersed with episodes of depression. While treatment developments and understanding the disruptive nature of this illness have focused on these episodes, it is also evident that some patients may have chronic week-to-week mood instability. This is also a major morbidity. The longitudinal pattern of this mood instability is poorly understood as it has, unti ... [truncated at 450 characters in length]|
|Author||Bonsall, MB; Wallace-Hadrill, SM; Holmes, EA; et al|
|Subject||Psychiatry Bipolar disorder Zoological sciences Ecology (zoology)|
Pathological gambling is a maladaptive behaviour associated with diminished self-control over persistent compulsive gambling behaviour despite negative consequences. A significant revision to the clinical perspective of pathological gambling is underway, and the disorder will likely be recognized as a behavioural addiction in the fifth edition of Diagnostic and Statistical Manual of Mental Disorders. However, the neurobiological, cognitive and ... [truncated at 450 characters in length]
|Creator||Patrick Daniel Worhunsky;|
|Subject||Psychiatry Behavioural Neuroscience Clinical Neuropsychology|
D-amino acid oxidase (DAO) is a flavin-dependent enzyme that is expressed in the mammalian brain. It is the metabolising enzyme of several D-amino acids, including D serine, which is an endogenous agonist at the glycine co-agonist site of the glutamatergic NMDA receptor. As such, regulation of D serine levels in the brain by DAO may indirectly modulate the activity of NMDA receptors. The expression and activity of DAO have been reported to be ... [truncated at 450 characters in length]
|Creator||Jill Frances Betts;|
|Subject||Medical Sciences Neuroscience Neuropathology Psychiatry Molecular neuropathology Psychopharmacology Psychotic illness|
The development of predictive biomarkers in neuroscience is increasingly enabling bioprediction of adverse behavioural events, from psychosis to impulsive violent reaction. Because many brain-based disorders can be thought of as end-states of a long development, bioprediction carries immense therapeutic potential.
In this thesis, I analyse issues raised by the development of bioprediction of brain-based disorder. I argue that ethical an ... [truncated at 450 characters in length]
|Creator||Matthew L Baum;|
|Subject||Medical Sciences Psychiatry Neuroscience Molecular neuropathology Psychotic illness Neurology Ethics (Moral philosophy) Ethics of the biosciences Practical ethics Criminology ? Sentencing and Punishment Public Health|
Background: Depression in fathers in the postnatal period is associated with an increased risk of child behaviour problems. A key potential pathway of risk transmission is exposure of the child to negative cognitions and affect in the context of early parenting. This study examines paternal speech during face-to-face father-infant interactions at 3 months.
Method: Currently depressed (n=19) and non-depressed (n=19) fathers were individua ... [truncated at 450 characters in length]
|Author||V. Sethna; L. Murray; P. G. Ramchandani;|