Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
|Abstract||Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these sites have not been elucidated. Here, we report on three novel and diverse protein kinase structures that reveal an exchanged activation segment conformation. This dimeric arrangement results in an active ... [truncated at 450 characters in length]|
|Author||Pike, Ashley C W; Rellos, Peter; Niesen, Frank H; et al|
|Subject||Dimerization Humans Models, Molecular Phosphorylation Protein Kinases Protein Structure, Tertiary chemistry metabolism|
Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.
|Abstract||Fibrodysplasia Ossificans Progressiva (FOP) is a rare, heritable condition typified by progression of extensive ossification within skeletal muscle, ligament and tendon together with defects in skeletal development. The condition is easily diagnosed by the presence of shortened great toes and there is severe advancement of disability with age. FOP has been shown to result from a point mutation (c.617G>A) in the ACVR1 gene in almost all patients r ... [truncated at 450 characters in length]|
|Author||Petrie, Kirsten A; Lee, Wen Hwa; Bullock, Alex N; et al|
|Subject||Activin Receptors, Type I Adolescent Enzyme Activation Female Humans Middle Aged Mutation, Missense Myositis Ossificans Phenotype Point Mutation Protein Kinases genetics genetics|
Insights into protein kinase regulation and inhibition by large scale structural comparison.
|Abstract||Protein structure determination of soluble globular protein domains has developed into an efficient routine technology which can now be applied to generate and analyze structures of entire human protein families. In the kinase area, several kinase families still lack comprehensive structural analysis. Nevertheless, Structural Genomics (SG) efforts contributed more than 40 kinase catalytic domain structures during the past 4 years providing a rich ... [truncated at 450 characters in length]|
|Author||Eswaran, Jeyanthy; Knapp, Stefan;|
|Subject||Animals Humans Protein Kinase Inhibitors Protein Kinases Protein Structure, Tertiary Structure-Activity Relationship chemistry chemistry genetics metabolism|